Emerging Diseases
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QESTION
Why would ARS Scientists from the Plum Island Animal Research Facility, test Japanese Encephalitis vaccine on HUMANS?
Taken from ARS webpage
Taken from ARS page:
INDUCTION OF JAPANESE ENCEPHALITIS VIRUS-SPECIFIC CYTOTOXIC T
LYMPHOCYTES IN HUMAN BY POXVIRUS-BASED JE VACCINE CANDIDATES

Author(s):
KONISHI EIJI
KURANE ICHIRO
MASON PETER W
SHOPE ROBERT E
KANESA-THASAN NIRANJAN
SMUCNY JOHN J
HOKE CHARLES H
ENNIS FRANCIS A

Interpretive Summary:
Japanese encephalitis (JE) is a mosquito-borne viral disease that infects pigs, horses, and humans in many areas of the Far East and
Southeast Asia. Japanese encephalitis virus (JEV) infection of pregnant swine can cause abortion, and many of the successfully
delivered offspring suffer irreversible brain damage. JEV infections of humans or horses can result in a severe brain infection known as
encephalitis. Current vaccines for JE consist of chemically inactivated viruses prepared from JEV-infected suckling mice. Preparation of
these vaccines is dangerous and time consuming. In an attempt to develop new vaccines, we have been engineered and tested
genetically engineered poxviruses that encode a some of the protein immunogens of JEV. These poxviruses have been shown to be safe
and effective vaccines for JE in mice and swine. The current work describes the further characterization of these recombinant
poxviruses. Specifically, we have demonstrated that these viruses can be safely administered to human volunteers, and that the
vaccinees produced immune responses, including antibodies and cytotoxic (killer) T- lymphocytes (cells) that are capable of destroying
JEV-infected cells. However, immune responses were reduced in vaccinees who had a history of vaccination against smallpox.

Keywords:
virology aphthovirus disease recombinant dna receptor

Contact:
P O BOX 848
GREENPORT LI
ORIENT POINT
NY 11944
FAX: (516)323-2507
Email: PeterMas@ASRR.ARSUSDA.GOV

Approved Date: 1999-01-14


TEKTRAN
United States Department of Agriculture
Agricultural Research Service

Updated: 1999-01-16


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